SDSU Systems Neuroscience (SCI 596)

Marty Sereno — email: msereno - AT - sdsu
time: MWF 9:00 - 9:50 AM (graduate: F 8:00 - 8:50)
location: SSW 2667 (Learning Glass Studio, Student Services West
take copious notes, exams heavily based on lectures

Learning Glass lecture recordings
Neuroscience papers (background reading)
Neuroscience reference texts:
    Squire, Berg et al., eds. (2008/2013) Fundamental Neuroscience, 3rd/4th ed.
    Kandel, Jessell, Schwartz, eds. (2008/2012) Principles of Neural Science, 5th/6th ed.
    Nieuwenhuys, Voogd, van Huijzen (2008) The Human Central Nervous System, 4th ed.
Neuroscience ugrad textbooks:
    Nicholls et al. (2012) From Neuron to Brain, 5th ed.
    Bear, Connors, and Paradiso (2006/2015) Neuroscience: Exploring the Brain, 3rd/4th ed.

multiple question short-answer, each question with a few subsections, examples given in lecture
undergraduate: 2 midterms, final — short-answer (midterms: 30% each, final: 40%)
graduate: 2 midterms, final (midterms: 24% each, final: 32%), and short final paper (20%)
old pdf answer keys from my similar UCSD Systems Neuroscience course (2007) here and here

Learning Objectives:
Students will be able to do the following:
    (1) explain neuronal chemistry, electronics, development, evolution
    (2) diagram neuroanatomical structures and connections in visual, somatosensory, auditory, motor, limbic systems
    (3) analyze processing stages in visual, somatosensory, auditory, motor, limbic systems in signals-and-systems view
N.B.: consult with me if a disability hinders your performance so we can use University resources to maximize learning

Lecture Topics — Spring 2017 (pdf)

Week of Jan 16 (Wed/Fri, first class Jan 18)Introduction

introduction to course
membrane (Nernst) potential (N.B.: all other classes in SSW 2667!)

Week of Jan 23 (Mon/Wed/Fri)Cellular Physiology

action potential, voltage-gated channels
post-synaptic potentials, ligand-gated channels
NMDA channels, spike-timing-dependent plasticity

Week of Jan 30 (Mon/Wed/Fri)Relation to Neural Models

dendritic propagation, equivalent circuits
relation to simple Hebbian network models
relation to simple attractor network models

Week of Feb 06 (Mon/Wed/Fri)Neural Development

gastrulation, neural plate, neural tube, optic cup
cylindrical coordinate system, temporal lobe formation
the 'rule of Sereno'

Week of Feb 13 (Mon/Wed/Fri)Visual System I

retinal circuitry and streams
dLGN (layers, non-lagged/lagged)
visual map structure (conformal maps)

Week of Feb 20 (Mon/Wed/Fri)Visual System II

general scheme for cortical layers
edges, brightness, and primary motion in V1
1st midterm review
1st Midterm Exam — Fri, Feb 24, SSW 2650

Week of Feb 27 (Mon/Wed/Fri)Visual System III

aperture problems in general (color intro)
aperture problems for visual pattern translation, optical flow
visual attention
visual object recognition

Week of Mar 06 (Mon/Wed/Fri)Somatosensory System I

somatosensory receptors types
arm diagram (length, force, alpha/gamma motoneurons)
somatosensory pathways (dorsal column, spinothalamic, spinocerebellar)
somatosensory cortical areas
somatosensory map plasticity

Week of Mar 13 (Mon/Wed/Fri)Auditory System I

auditory transduction and hair cell receptors
monaural cochlear nuclei responses

Week of Mar 20 (Mon/Wed/Fri)Auditory System II

auditory brainstem sound localization
echolocation and speech sound processing
auditory cortical areas

Week of Mar 27SPRING BREAK

Week of Apr 03 (Mon/Wed/Fri)Motor System I

gaze stabilization (VOR, OKN, pursuit)
superior colliculus retinal and motor maps
sensorimotor coordinate transforms (double-step remembered saccade)
multisensory map interactions — sup. collic visual/auditory
multisensory map interactions — VIP somatosensory/visual

Week of Apr 10 (Mon/Wed/Fri)Motor System II

motor system overview
cortical and spinal pattern generators
motor cortex
2nd midterm review
2nd Midterm Exam — Fri, Apr 14, SSW 2650

Week of Apr 17 (Mon/Wed/Fri)Motor System III

cerebellum anatomy, physiology
cerebellum and learning/conditioning
connectional/functional overview striatum
striatum and hierachical sequencing

Week of Apr 24 (Mon/Wed/Fri)Limbic System

connectional overview limbic system
H.M./intermediate term memory vs. inertial guidance
place cells
head direction cells
grid cells
models: theta rhythms, attractor networks

Week of May 01 (Mon/Wed, last class May 03)Neuroimaging MRI/EEG/MEG

hardware, spin vs. precession, Bloch equation
spin echo and gradient echo
phase-sensitive detection, intro to complex numbers
frequency-encoding — incorrect and correct intuitions
neural source of EEG/MEG signals
current source density, linear foward solution
course review

May 08 (Mon, 8-10 AM)Final Exam

Final Exam
Graduate students: final paper due May 11

last modified: Oct 02, 2017
Scanned/video'd class notes (pdf, links above) © 2017 Martin I. Sereno
Supported by NSF 0224321, NIH MH081990, Royal Society Wolfson