SDSU Systems Neuroscience (SCI 596)

Course Flyer:

Marty Sereno — email: msereno - AT - sdsu
time: MWF 9:00 - 9:50 AM (graduate: F 8:00 - 8:50)
location: SSW 2667 (Learning Glass Studio, Student Services West)
take lots of notes to help comprehension, exams heavily based on lectures

Learning Glass lecture recordings
Neuroscience papers (background reading)
Neuroscience reference texts:
    Squire, Berg et al., eds. (2008/2013) Fundamental Neuroscience, 3rd/4th ed.
    Kandel, Jessell, Schwartz, eds. (2008/2012) Principles of Neural Science, 5th/6th ed.
    Nieuwenhuys, Voogd, van Huijzen (2008) The Human Central Nervous System, 4th ed.
Neuroscience ugrad textbooks:
    Nicholls et al. (2012) From Neuron to Brain, 5th ed.
    Bear, Connors, and Paradiso (2006/2015) Neuroscience: Exploring the Brain, 3rd/4th ed.

multiple question short-answer, each question with a few subsections, examples given in lecture
undergraduate: 2 midterms, final — short-answer (midterms: 30% each, final: 40%)
graduate: 2 midterms, final (midterms: 24% each, final: 32%), and short final paper (20%)
old pdf answer keys from my similar UCSD Systems Neuroscience course (2007) here and here

Learning Objectives:
Students will be able to do the following:
    (1) explain neuronal electrochemistry, development, evolution, relate to dendritic/Hebbian/attractor models
    (2) diagram neuroanatomical structures/connections low to high level in visual, somatosensory, auditory systems
    (3) analyze sequential processing stages in visual, somatosensory, and auditory systems from signals and systems view
    (4) diagram structures/connections in superior colliculus, cerebellum, striatum, motor cortex, and limbic system
    (5) describe neural models of eye movement planning, hierarchical motor control, representation of position/orientation
N.B.: consult with me if a disability hinders your performance so we can use University resources to maximize learning

Lecture Topics — Spring 2018 (syllabus pdf)

Week of Jan 15 (Wed/Fri, first class Jan 17)Introduction

introduction to course
membrane (Nernst) potential

Week of Jan 22 (Mon/Wed/Fri)Cellular Physiology

action potential, voltage-gated channels
post-synaptic potentials, ligand-gated channels
NMDA channels, spike-timing-dependent plasticity

Week of Jan 29 (Mon/Wed/Fri)Relation to Neural Models

dendritic propagation, equivalent circuits
relation to simple Hebbian network models
relation to simple attractor network models

Week of Feb 05 (Mon/Wed/Fri)Neural Development

gastrulation, neural plate, neural tube, optic cup
cylindrical coordinate system, temporal lobe formation
the 'rule of Sereno'

Week of Feb 12 (Mon/Wed/Fri)Visual System I

retinal circuitry and streams
dLGN (layers, non-lagged/lagged)
visual map structure (conformal maps)

Week of Feb 19 (Mon/Wed/Fri)Visual System II

general scheme for cortical layers
edges, brightness, and primary motion in V1
1st midterm review
1st Midterm Exam — Fri, Feb 23, location TBA

Week of Feb 26 (Mon/Wed/Fri)Visual System III

aperture problems in general (color intro)
aperture problems for visual pattern translation, optical flow
visual attention
visual object recognition

Week of Mar 05 (Mon/Wed/Fri)Somatosensory System

somatosensory receptor types
arm diagram (length, force, alpha/gamma motoneurons)
somatosensory pathways (dorsal column, spinothalamic, spinocerebellar)
somatosensory cortical areas, discontinuities
somatosensory map plasticity

Week of Mar 12 (Mon/Wed/Fri)Auditory System I

hair cell receptors, lateral line, electric fish
cochlear structure/transduction, 1D vs. 2D maps
monaural cochlear nuclei responses

Week of Mar 19 (Mon/Wed/Fri)Auditory System II

auditory brainstem sound localization
echolocation and speech sound processing
auditory cortical areas

Week of Mar 26SPRING BREAK

Week of Apr 02 (Mon/Wed/Fri)Motor System I

gaze stabilization (VOR, OKN, pursuit)
superior colliculus retinal and motor maps
sensorimotor coordinate transforms (double-step remembered saccade)
multisensory map interactions — sup. collic visual/auditory
multisensory map interactions — VIP somatosensory/visual

Week of Apr 09 (Mon/Wed/Fri)Motor System II

motor system overview
cortical and spinal pattern generators
motor cortex
2nd midterm review
2nd Midterm Exam — Fri, Apr 13, location TBA

Week of Apr 16 (Mon/Wed/Fri)Motor System III

cerebellum anatomy, physiology
cerebellum and learning/conditioning
connectional/functional overview striatum
striatum and hierachical sequencing

Week of Apr 23 (Mon/Wed/Fri)Limbic System

connectional overview limbic system
H.M./intermediate term memory vs. inertial guidance
place cells
head direction cells
grid cells
models: theta rhythms, attractor networks

Week of Apr 30 (Mon/Wed, last class May 02)Neuroimaging MRI/EEG/MEG

hardware, spin vs. precession, Bloch equation
spin echo and gradient echo
phase-sensitive detection, intro to complex numbers
frequency-encoding — incorrect and correct intuitions
neural source of EEG/MEG signals
current source density, linear foward solution
course review

May 07 (Mon, 8-10 AM)Final Exam

Final Exam
Graduate students: final paper due May 10

last modified: Jan 23, 2018
Scanned/video'd class notes (pdf, links above) © 2018 Martin I. Sereno
Supported by NSF 0224321, NIH MH081990, Royal Society Wolfson